CALR Mutation Underlying Silent Stroke

Silent stroke in patients with acute thrombotic stroke

Introduction: Brain stroke is the most common neurologic disorder and also the most common cause of mortality and morbidity in neurtologic patients. Thanks to new methods of radiography such as MRI, brain vascular lesions including silent stroke are demonstrated more carefully. This study considers the frequency of silent stroke in patients with acute thrombotic stroke in Rafsanjan by using M...

CALR mutation characterization in myeloproliferative neoplasms

Identification of somatic frameshift mutations in exon 9 of the calreticulin gene (CALR) in myeloproliferative neoplasms (MPNs) in December of 2013 has been a remarkable finding. It has provided a new molecular diagnostic marker, particularly in essential thrombocythemia (ET) and primary myelofibrosis (PMF), where is the second most common altered gene after JAK2V617F. There are two main types ...

Silent stroke and carotid stenosis.

BACKGROUND AND PURPOSE Silent cerebral infarction is often found on computed tomographic scan in patients with asymptomatic carotid stenosis, but its relation to the arterial stenosis is uncertain. METHODS We compared computed tomographic scans and carotid Doppler in 115 patients with asymptomatic carotid stenosis, 203 with carotid transient ischemic attacks and carotid stenosis, and 63 with ...

Silent stroke: not listened to rather than silent.

BACKGROUND AND PURPOSE The prevalence of silent brain infarcts varies from 8% to 28% in the general elderly population. Silent brain infarcts are associated with increased risk of subsequent stroke and cognitive dysfunction. By definition, silent strokes lack clinically overt stroke-like symptoms and fail to come to clinical attention; however, impaired recall of symptoms may be a potential con...

Silent infarctions in first-ever stroke patients.